Trifluoroacetic acid → Trifluoroacetic acid
反応式
CC(OC([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)=O)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[NH2:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([OH:16])[CH2:12][CH2:11]1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]参加物
5
実験手順
Tert-butyl ((1r,4r)-4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 mL) was treated with trifluoroacetic acid (5 mL) at 0° C. for 10 minutes and at room temperature for 30 minutes. The reaction mixture was concentrated and dried in vacuo to provide the title compound as a trifluoroacetic acid salt.
後処理
- concentrationThe reaction mixture was concentrated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-59005952259743b0837205f4d592e46b
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546399B2
反応ノート
読み込み中…