HCID 58254864、化合物 → tert-butyl N-(3-phenylpyrrolidin-3-yl)carbamate

HRID 10364ノート

反応式

HRID 10364 の反応式
[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:12][CH2:11][N:10](CC2C=CC=CC=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 58254864HCID 58254864、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 21041211tert-butyl N-(3-phenylpyrrolidin-3-yl)carbamate収率 99.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(1-Benzyl-3-phenylpyrrolidin-3-yl)carbamic acid tert-butyl ester (Hagen S. E., Domagala J. M., Heifetz C. L., Sanchez J. P., Solomon M., J. Med. Chem., 1990; 33(2):849–854) (2.79 g, 7.9 mmol) in 100 mL of methanol is treated with 1.0 g of 20% Pd/C and shaken for 17 hours under 50 psi of hydrogen. The solution is filtered and concentrated to afford 2.07 g of the title compound as a foam; MS EI+: m/z 263 (MH+).

後処理

  1. filtrationThe solution is filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-07031ad2da014fb091396545797a8366
出典データセット
uspto-grants-2006_08
特許番号
US07094780B1

反応ノート

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