Sodium hydride → methyl [1-((2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(4-fluorophenyl)sulfonyl]amino}butyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetate

HRID 1036630ノート

反応式

HRID 1036630 の反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:2]1.[H-].[Na+].[Si:17]([O:24][CH2:25][CH2:26][C@@H:27]1[CH2:29][N:28]1[S:30]([C:33]1[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=1)(=[O:32])=[O:31])([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18].[Cl-].[NH4+]>CN(C=O)C.C(OCC)(=O)C>[CH3:14][O:13][C:11](=[O:12])[CH2:10][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:1]([CH2:29][C@H:27]([NH:28][S:30]([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)(=[O:32])=[O:31])[CH2:26][CH2:25][O:24][Si:17]([C:20]([CH3:23])([CH3:21])[CH3:22])([CH3:18])[CH3:19])[CH:2]=1

参加物

7

反応物 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 25067325Methyl 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetateHCID 58399169(2R)-2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-[(4-fluoro-phenyl)sulfonyl]aziridine

生成物 1

HCID 86655913methyl [1-((2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(4-fluorophenyl)sulfonyl]amino}butyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetate収率 37.6%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒2 回HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

To a cooled solution at 0° C. of methyl 1H-pyrrolo[2,3-b]pyridin-3-ylacetate (1.1 g, 5.8 mmol) in DMF (12 mL) was added 60% NaH in oil (0.26 g, 6.4 mmol, 1.1 equiv.). After a period of 10 min at room temperature, the reaction mixture was cooled to 0° C. and a DMF solution (12 mL) of (2R)-2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-[(4-fluorophenyl)-sulfonyl]aziridine (2.0 g, 5.8 mmol) was added. The reaction was aged 0.5 h at room temperature and poured over saturated ammonium chloride and ethyl acetate. The organic phase was separated, dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by combiflash (hexane to 50% ethyl acetate in hexane) to provide 1.2 g of the title compound.

後処理

  1. waitThe reaction was aged 0.5 h at room temperature
  2. customThe organic phase was separated
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. customThe residue was purified by combiflash (hexane to 50% ethyl acetate in hexane)

出典と根拠

ORDレコード
ord-a603c40d6dda47a2ac6a9d622813d31b
出典データセット
uspto-grants-2013_10
特許番号
US08546422B2

反応ノート

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