Thionyl Chloride → HCID 13340573、化合物

HRID 1037583ノート

反応式

HRID 1037583 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>>[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([Cl:14])=[O:11])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 1372144-Iodophenylacetic acid

生成物 1

HCID 13340573HCID 13340573、化合物

反応条件

温度
100 °C

実験手順

Under an argon atmosphere, to 4-iodophenylacetic acid (11) (prepared by the process described in Chen, Q.-H. et al., Bioorg. Med. Chem. 14, 7898-7909 (2006)) (1.06 g, 4.05 mmol) was added thionyl chloride (5.00 mL, 68.6 mmol) and heated to reflux (100° C.) for 1.5 h. After cooling to room temperature, the mixture was concentrated under reduced pressure to give 4-iodophenylacetyl chloride (12) as a brown oily crude product, which was used in the next reaction without further purification.

後処理

  1. temperatureheated
  2. temperatureAfter cooling to room temperature
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5d2d0b44fc0e41c5a968242015e9a317
出典データセット
uspto-grants-2013_10
特許番号
US08546568B2

反応ノート

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