Hydrochloric Acid → Naltrexone Hydrochloride

HRID 1037635

反応式

HRID 1037635 の反応式
[CH2:1]1[CH:3]([CH2:4][N:5]2[C@@H:15]3[CH2:16][C:17]4[CH:22]=[CH:21][C:20]([OH:23])=[C:19]5[O:24][CH:9]6[C:10]([CH2:12][CH2:13][C@:14]3([OH:25])[C@:8]6([C:18]=45)[CH2:7][CH2:6]2)=[O:11])[CH2:2]1.[ClH:26]>O>[CH:22]1[C:17]2[CH2:16][C@H:15]3[N:5]([CH2:4][CH:3]4[CH2:1][CH2:2]4)[CH2:6][CH2:7][C@:8]45[C@H:9]([C:10]([CH2:12][CH2:13][C@@:14]34[OH:25])=[O:11])[O:24][C:19]([C:18]=25)=[C:20]([OH:23])[CH:21]=1.[ClH:26]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21159611Naltrexone Base

生成物 1

HCID 5485201Naltrexone Hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
72.5 °C

実験手順

70 kg Naltrexone base is taken in 210 Lit DM water and pH was adjusted to ˜2.0 with Conc. HCl and heated to 70-75° C. to get clear solution, filtered to make particle free and slowly cooled to 2-5° C. in 6-8 hrs period, filtered and then dried. The base was generated from filtrate by treatment with sodium hydroxide and converted to HCl salt by repeating the above mentioned process. Yield: 59.8 kg

後処理

  1. customto get clear solution
  2. filtrationfiltered
  3. temperatureslowly cooled to 2-5° C. in 6-8 hrs period
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-255dff4051a1443da45aa8f55e091af9
出典データセット
uspto-grants-2013_10
特許番号
US08546572B2

関連ノート

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