Methanol → HCID 59579790、化合物

HRID 1037786ノート

反応式

HRID 1037786 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14])([O-])=O.CO>[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14]

参加物

4

反応物 2

HCID 887MethanolHCID 595797305-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one

生成物 1

HCID 59579790HCID 59579790、化合物

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Into a round bottom flask was combined 5-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one (0.85 g, 0.0029 mol), Palladium/C (0.05 g, 0.0005 mol) and methanol (200 mL, 5 mol). The reaction mixture was stirred under hydrogen balloon at room temperature for 40 mins. The mixture was filtered over celite, MeOH was removed and the solid was yield (0.54 mg). MS m/z=266.0 (M+1). 1H NMR (DMSO) δ 8.55 (d, J=4.8 Hz, 1 H), 7.77 (td, J=7.7, 1.8 Hz, 1 H); 7.44 (d, J=7.8 Hz, 1 H), 7.35-7.25 (m, 3 H), 7.17 (t, J=7.8 Hz, 1 H), 6.95-6.85 (m, 1 H), 6.78 (d, J=7.8 Hz, 1 H), 6.28 (q, J=7.2 Hz, 1 H), 5.66 (s, 2 H), 1.75 (d, J=7.2 Hz, 3 H).

後処理

  1. customInto a round bottom flask was combined
  2. filtrationThe mixture was filtered over celite, MeOH
  3. customwas removed
  4. customthe solid was yield (0.54 mg)

出典と根拠

ORDレコード
ord-315a62beed394b28a6a13ca24c75e09b
出典データセット
uspto-grants-2013_10
特許番号
US08546579B2

反応ノート

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