Potassium Nitrate → 5-nitro-1H-indazole-3-carboxylic Acid

HRID 1037999

反応式

HRID 1037999 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[N:2]1.[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[N+:13]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[C:3]2[C:10]([OH:12])=[O:11])([O-:15])=[O:14]

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 78250Indazole-3-carboxylic acid2 回

生成物 1

HCID 71446525-nitro-1H-indazole-3-carboxylic Acid収率 77.8%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a suspension of indazole-3-carboxylic acid (compound 53, 3.0 g, 18 mmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried and concentrated to give compound 54 (2.9 g) as the major isomer.

後処理

  1. extractionextracted three times with ethyl acetate
  2. washThe combined organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0a0fdad625654d2aac3086ba58f05015
出典データセット
uspto-grants-2013_10
特許番号
US08546404B2

関連ノート

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