Potassium Nitrate → 5-nitro-1H-indazole-3-carboxylic Acid

HRID 1038002

反応式

HRID 1038002 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[N:2]1.[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[N+:13]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[C:3]2[C:10]([OH:12])=[O:11])([O-:15])=[O:14]

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 78250Indazole-3-carboxylic acid

生成物 1

HCID 71446525-nitro-1H-indazole-3-carboxylic Acid収率 77.8%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a suspension of indazole-3-carboxylic acid (3.0 g, 18 mmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate (90 mL total). The combined organic layer was washed with brine, dried and concentrated to give (54) (2.9 g) as the major product.

後処理

  1. extractionextracted three times with ethyl acetate (90 mL total)
  2. washThe combined organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-32e0917c4fb546c0a17cd670bb5ee70d
出典データセット
uspto-grants-2013_10
特許番号
US08546404B2

関連ノート

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