Water → Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate

HRID 1038031

反応式

HRID 1038031 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].[Br:25]Br.O>C(Cl)(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([Br:25])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 10796Cesium carbonateHCID 24408BromineHCID 21925505tert-Butyl 4-(thiazol-2-yl)piperazine-1-carboxylate

生成物 1

HCID 34180719Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate収率 95%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a mixture containing 4-thiazol-2-yl-piperazine-1-carboxylic acid tert-butyl ester (0.5 g, 1.9 mmol) and cesium carbonate (0.62 mmol) in chloroform (5 mL) at 0° C., bromine (110 mL) was added through a syringe. After the addition, the reaction mixture was stirred at room temperature for 1 hour. Water was added and the organic layer was collected and dried over sodium sulfate. After removal of solvent, 0.6 g of product was obtained (95% yield).

後処理

  1. additionAfter the addition
  2. customthe organic layer was collected
  3. dry with materialdried over sodium sulfate
  4. customAfter removal of solvent

出典と根拠

ORDレコード
ord-c2004064000e4876899365a0191bb840
出典データセット
uspto-grants-2013_10
特許番号
US08546404B2

関連ノート

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