Triisopropyl borate → (2,6-Dimethylpyridin-4-yl)boronic acid
反応式
Br[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[CH:3]=1.[B:10](OC(C)C)([O:15]C(C)C)[O:11]C(C)C.[Li]CCCC>C1COCC1>[CH3:8][C:6]1[CH:7]=[C:2]([B:10]([OH:15])[OH:11])[CH:3]=[C:4]([CH3:9])[N:5]=1参加物
5
実験手順
4-Bromo-2,6-dimethyl-pyridine (910 mg, 4.9 mmol) and triisopropyl borate (2.3 mL, 10 mmol) in THF (10 mL) were cooled in a −78° C. bath. BuLi (2.7 M, 7 mL) was added in drop wise. After 3 hrs, the bath was removed. The reaction was acidified with 1N HCl till pH=1. The separated aqueous layer was neutralized with NaOH and subsequently extracted with ethyl acetate. A crude white solid was obtained (800 mg) as the title compound.
後処理
- customthe bath was removed
- extractionsubsequently extracted with ethyl acetate
出典と根拠
- ORDレコード
- ord-70c2b3acf9cc41d79e2de41243a555de
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546404B2
反応ノート
読み込み中…