Diisopropylethylamine → HCID 86630173、化合物

反応式

[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH:21][C:22]([C:24]4([O:29][CH3:30])[CH2:28][CH2:27][NH:26][CH2:25]4)=[O:23])[CH:19]=3)[NH:14][N:13]=2)=[CH:8][CH:7]=1.Cl[CH2:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([C:41]2[CH:46]=[CH:45][C:44]([C:47]3[N:52]=[CH:51][CH:50]=[CH:49][N:48]=3)=[C:43]([F:53])[CH:42]=2)[CH2:37][CH2:36]1)=[O:34].C(N(C(C)C)CC)(C)C>CN(C)C=O>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH:21][C:22]([C:24]4([O:29][CH3:30])[CH2:28][CH2:27][N:26]([CH2:32][C:33]([N:35]5[CH2:40][CH2:39][N:38]([C:41]6[CH:46]=[CH:45][C:44]([C:47]7[N:48]=[CH:49][CH:50]=[CH:51][N:52]=7)=[C:43]([F:53])[CH:42]=6)[CH2:37][CH2:36]5)=[O:34])[CH2:25]4)=[O:23])[CH:19]=3)[NH:14][N:13]=2)=[CH:8][CH:7]=1

参加物

実験手順

3-Methoxy-pyrrolidine-3-carboxylic acid {3-[4-(2-methoxy-ethoxy)-phenyl]-1H-indazol-5-yl}-amide (10AB) (50 mg, 0.103 mmol, 1 equiv) and 2-Chloro-1-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethanone (7AB) (42 mg, 0.124 mmol, 1.2 equiv) were weighed out in a flask and to it was added N,N-dimethylformamide (3 mL) and diisopropylethylamine (26.6 mg, 36 uL, 0.206 mmol, 2 equiv). The reaction content was stirred at room temperature, overnight.