2-Methoxybenzene-1,3,5-tricarboxylic acid → 2-Hydroxy-1,3,5-benzenetricarboxylic acid
反応式
C[O:2][C:3]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]([C:12]([OH:14])=[O:13])=[CH:5][C:4]=1[C:15]([OH:17])=[O:16]>Br>[OH:2][C:3]1[C:4]([C:15]([OH:17])=[O:16])=[CH:5][C:6]([C:12]([OH:14])=[O:13])=[CH:7][C:8]=1[C:9]([OH:11])=[O:10]参加物
3
反応条件
- 温度
- 150 °C
実験手順
A mixture of 2-methoxy-benzene-1,3,5-tricarboxylic acid (3) (24 g, 0.1 mol) and 48% HBr (500 mL) was placed in a 1 L bound bottom flask. The reaction mixture was heated to reflux at 150° C. for 48 h. The progress of the deprotection was monitored by proton NMR. When the reaction was complete, the hydrobromic acid was removed under reduced pressure, and the residue was mixed with small amount of water. The deprotected triacid (13) was collected by filtration; yield 17 grams (75%).