Water → 1-Bromo-4-iodo-2-(phenoxymethyl)benzene

HRID 1038350ノート

反応式

HRID 1038350 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16]Cl.[Na+].[I-].O>[OH-].[K+].CC(C)=O>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][C:10]=1[CH2:16][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

7

反応物 4

HCID 962WaterHCID 996PhenolHCID 5238Sodium IodideHCID 593463281-Bromo-2-(chloromethyl)-4-iodobenzene

生成物 1

HCID 593463231-Bromo-4-iodo-2-(phenoxymethyl)benzene

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 14797Potassium Hydroxide溶媒

反応条件

温度
50 °C

実験手順

Phenol (13 g) dissolved in aqueous 4 M KOH solution (60 mL) is added to 4-bromo-3-chloromethyl-1-iodo-benzene (41.0 g) dissolved in acetone (50 mL). NaI (0.5 g) is added and the resulting mixture is stirred at 50° C. overnight. Then, water is added and the resulting mixture is extracted with ethyl acetate. The combined extracts are dried (Na2SO4) and the solvent is evaporated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1).

後処理

  1. extractionthe resulting mixture is extracted with ethyl acetate
  2. dry with materialThe combined extracts are dried (Na2SO4)
  3. customthe solvent is evaporated under reduced pressure
  4. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 19:1)

出典と根拠

ORDレコード
ord-9036fc6a6da0426e91eb044c255eaa32
出典データセット
uspto-grants-2013_10
特許番号
US08551957B2

反応ノート

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