ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Sodium Carbonate → N-(3-((5-(4-cyanophenyl)thiazol-2-yl)amino)phenyl)methanesulfonamide

HRID 1038449
ノート
印刷プレビュー

反応式

HRID 1038449 の反応式
Br[C:2]1[S:6][C:5]([NH:7][C:8]2[CH:9]=[C:10]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH:11]=[CH:12][CH:13]=2)=[N:4][CH:3]=1.CC1(C)C(C)(C)OB([C:27]2[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=2)O1.[Cl-].[Li+].C([O-])([O-])=O.[Na+].[Na+]>CCCCCC.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:31]([C:30]1[CH:33]=[CH:34][C:27]([C:2]2[S:6][C:5]([NH:7][C:8]3[CH:9]=[C:10]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH:11]=[CH:12][CH:13]=3)=[N:4][CH:3]=2)=[CH:28][CH:29]=1)#[N:32]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 10340Sodium CarbonateHCID 433294Lithium ChlorideHCID 27346254-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 86674186N-(3-((5-bromothiazol-2-yl)amino)phenyl)methanesulfonamide

生成物 1

HCID 71471997N-(3-((5-(4-cyanophenyl)thiazol-2-yl)amino)phenyl)methanesulfonamide収率 89%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒
HCID 8058Hexane溶媒

反応条件

温度
100 °C

実験手順

To a mixture of N-(3-((5-bromothiazol-2-yl)amino)phenyl)methanesulfonamide 56 (0.159 g, 0.458 mmol), commercially available 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 57 (0.125 g, 0.545 mmol), Lithium chloride (0.038 g, 0.916 mmol) and tetrakis(triphenylphosphine)palladium (0.058 g, 0.05 mmol) in dry and degassed (using argon) 1,4-Dioxane (20 mL) was added aq. Na2CO3 (1M, 0.91 mL, 0.916 mmol). Reaction mixture was degassed again for 2-3 times for 10 minutes and resulting yellow mixture was stirred under argon at 100° C. for 14 hours. Reaction mixture was filtered through a small pad of celite and concentrated. Crude product was MPLC (Biotage) silica column chromatographed using Acetone:Hexane as an eluent to obtain N-(3-((5-(4-cyanophenyl)thiazol-2-yl)amino)phenyl)methanesulfonamide 58 (0.15 g, 89% yield). MS (ES) m/z 371 (M+H+).

後処理

  1. customin dry
  2. customdegassed (using argon) 1,4-Dioxane (20 mL)
  3. customReaction mixture
  4. customwas degassed again for 2-3 times for 10 minutes
  5. customresulting yellow mixture
  6. customReaction mixture
  7. filtrationwas filtered through a small pad of celite
  8. concentrationconcentrated
  9. customchromatographed

出典と根拠

ORDレコード
ord-7a4cf497dcda4c3e84c6c24cfa9ef864
出典データセット
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08551992B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート