Chlorophenyl isocyanate → 1-(2-Chloro-phenyl)-3-(6-chloro-pyrimidin-4-yl)-urea

HRID 1038701ノート

反応式

HRID 1038701 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]=[C:17]=[O:18]>C1COCC1>[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17]([NH:8][C:4]1[CH:3]=[C:2]([Cl:1])[N:7]=[CH:6][N:5]=1)=[O:18]

参加物

4

反応物 2

HCID 76833Chlorophenyl isocyanate2 回HCID 2380124-Amino-6-chloropyrimidine

生成物 1

HCID 860869821-(2-Chloro-phenyl)-3-(6-chloro-pyrimidin-4-yl)-urea収率 174.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 6-chloro-pyrimidin-4-ylamine (997 mg, 7.7 mmol) and 2-chlorophenyl isocyanate (0.46 mL, 3.85 mmol) in THF (20 mL) is refluxed for 4 h. A further amount of 2-chlorophenyl isocyanate (0.46 mL, 3.85 mmol) is added and the reaction mixture is refluxed for 28 h. The reaction mixture is cooled to RT, the precipitate is filtered to afford the title compound (1.9 g, 86%).

後処理

  1. temperaturethe reaction mixture is refluxed for 28 h
  2. filtrationthe precipitate is filtered

出典と根拠

ORDレコード
ord-783f840a770941c9856e0b181da665f4
出典データセット
uspto-grants-2013_10
特許番号
US08552002B2

反応ノート

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