Isatoic Anhydride → 2-amino-N-(pyridin-2-yl)benzamide

HRID 1038931

反応式

HRID 1038931 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1>O1CCOCC1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:4]

参加物

4

反応物 2

HCID 8359Isatoic AnhydrideHCID 104392-Aminopyridine

生成物 1

HCID 2763252-amino-N-(pyridin-2-yl)benzamide収率 54%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of isatoic anhydride 71 (8.7 g, 0.053 mol) and 2-aminopyridine (5 g, 0.06 mol) was heated in dioxane (30 mL) for 6-7 hours. After cooling, the solvent was evaporated in vacuo, the residue treated with water and recrystallized from EtOH/H2O to yield 72 (6 g, 54%).

後処理

  1. temperatureAfter cooling
  2. customthe solvent was evaporated in vacuo
  3. additionthe residue treated with water
  4. customrecrystallized from EtOH/H2O

出典と根拠

ORDレコード
ord-a4ba31314b7b40a2a3232c4beaa6d4cc
出典データセット
uspto-grants-2013_10
特許番号
US08552009B2

関連ノート

読み込み中…