5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 1039062

反応式

HRID 1039062 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

参加物

4

反応物 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

生成物 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (100 mg, 0.523 mmol) from step 1 of this example was added Pd/C (111 mg, 0.105 mmol) and methanol (5.2 mL). Set the reaction on Parr Shaker at 50 psi (345 kPa) for overnight. The solution was filtered through CELITE and rinsed with methanol to give the title compound as a white solid.

後処理

  1. customthe reaction on Parr Shaker at 50 psi (345 kPa) for overnight
  2. filtrationThe solution was filtered through CELITE
  3. washrinsed with methanol

出典と根拠

ORDレコード
ord-fbe714709af342a7b7b3c79361752d35
出典データセット
uspto-grants-2013_10
特許番号
US08552022B2

関連ノート

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