Ammonia → 5-Amino-2,3-dihydro-isoindol-1-one

HRID 1039087

反応式

HRID 1039087 の反応式
O.Cl.[N+:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][CH2:9]2)([O-])=O.N>CCO.[Fe]>[NH2:3][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][CH2:9]2

参加物

7

反応物 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 962WaterHCID 140056255-nitro-2,3-dihydro-1H-isoindol-1-one

生成物 1

HCID 219562395-Amino-2,3-dihydro-isoindol-1-one

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 702Ethanol溶媒

反応条件

温度
95 °C

実験手順

Iron powder (2.51 g, 45 mmol), water (0.97 ml) and HCl (37%, 0.74 ml), were added to a stirred suspension of the 5-nitroisoindolin-1-one (800 mg, 4.5 mmol) from step 2 of this example in EtOH (11.2 ml). The mixture was heated at 95° C. for 2 h. Ammonia (7N in MeOH) was added (1 mL) to make the pH of the mixture alkaline. The mixture was filtered to removed undissolved solids and the filter cake washed with EtOH (2×40 ml). The filtrate and organic washes were combined and concentrated in vacuum to give the titled compound.

後処理

  1. filtrationThe mixture was filtered
  2. customto removed undissolved solids
  3. washthe filter cake washed with EtOH (2×40 ml)
  4. concentrationconcentrated in vacuum

出典と根拠

ORDレコード
ord-c3d19c53996c4330be95266fb33456dd
出典データセット
uspto-grants-2013_10
特許番号
US08552022B2

関連ノート

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