Hydroxyamine hydrochloride → HCID 178452026、化合物

反応式

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@@H:10]([C:13]#[N:14])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:16][OH:17].C([O-])(O)=O.[Na+]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@@H:10]([C:13](=[NH:14])[NH:16][OH:17])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

実験手順

(R)-3-Cyano-pyrrolidine-1-carboxylic acid tert-butyl ester (2.04 g, 10.4 mmol), hydroxylamine hydrochloride (0.79 g, 11.4 mmol) and NaHCO3 (0.97 g, 11.6 mmol) were added to MeOH (24 mL) and the solution was heated to reflux. After 4 h, the reaction was cooled to room temperature and filtered through a fritted funnel. The solution was concentrated in vacuo. The residue was purified by reverse phase HPLC to afford (R)-3-(N-hydroxycarbamimidoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.28 g, 5.58 mmol, 54%) as a yellow foam.