HCID 178521699、化合物 → HCID 178507185、化合物
反応式
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][CH:17]=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:16]1[N:15]=[C:14]([C:11]2([NH2:10])[CH2:13][CH2:12]2)[NH:18][CH:17]=1参加物
4
実験手順
To a solution of [1-(4H-[1,2,4]triazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (60 mg, 0.23 mmol) in MeOH (5 mL) was added 10% Pd/C (60 mg). The reaction mixture was stirred under H2 atmosphere (balloon) for 1.5 h. The reaction mixture was filtered through diatomaceous earth. The solvent was concentrated in vacuo and dried under high vacuum to afford 28 mg of the title compound, m/z 125.5 [M+1]+.
後処理
- filtrationThe reaction mixture was filtered through diatomaceous earth
- concentrationThe solvent was concentrated in vacuo
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-b1cbcd54f9224bd88a8376b29afa1e1f
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08552205B2
反応ノート
読み込み中…