Trifluoroacetic acid → (2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid

HRID 1040500ノート

反応式

HRID 1040500 の反応式
C(OC(=O)[NH:7][C@H:8]([C:16](=[O:27])[NH:17][C:18]1([C:21]2[N:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:20][CH2:19]1)[C@H:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])(C)(C)C.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[NH2:7][C@@H:8]([C@H:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH3:10])[C:16]([NH:17][C:18]1([C:21]2[N:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:19][CH2:20]1)=[O:27]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67390977[(1S,2R)-2-tert-butoxy-1-(1-pyrimidin-2-yl-cyclopropylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

生成物 1

HCID 67389830(2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

[(1S,2R)-2-tert-butoxy-1-(1-pyrimidin-2-yl-cyclopropylcarbamoyl)-propyl]-carbamic acid tert-butyl ester (0.17 g, 0.45 mmol) was dissolved in DCM (1 mL) and to this was added TFA (0.2 mL). The reaction was allowed to stir at RT for 24 h. The solvent was removed under reduced pressure and the residue triturated with Et2O to give (2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid (0.16 g, 0.45 mmol) as a white solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue triturated with Et2O

出典と根拠

ORDレコード
ord-ff001e8bbfca4171a3d9c63355f09863
出典データセット
uspto-grants-2013_10
特許番号
US08552205B2

反応ノート

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