HCID 178526576、化合物 → HCID 178507485、化合物

HRID 1041222ノート

反応式

HRID 1041222 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:11][CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1)([O-])=O>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C:13]1[N:14]=[C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH2:1])[NH:11][CH:12]=1

参加物

4

反応物 1

HCID 178526576HCID 178526576、化合物

生成物 1

HCID 178507485HCID 178507485、化合物収率 94.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-(2-Nitro-phenyl)-4-trifluoromethyl-1H-imidazole (1.50 g, 5.83 mmol) was dissolved in Methanol (35 mL) and solution was carefully added to 10% Palladium on Carbon (90:10, carbon black:Palladium, 0.500 g) under nitrogen. The reaction was then hydrogenated at 55 psi until HPLC showed consumption of starting material (˜4 hours). Catalyst was removed via filtration and the filtrate was reduced en vacuo to afford 1.25 grams (94%) of the desired product. LC/MS (ESI): 288.09.

後処理

  1. customconsumption of starting material (˜4 hours)
  2. customCatalyst was removed via filtration

出典と根拠

ORDレコード
ord-9f7ee847d5ea4c45b725ae57468317d4
出典データセット
uspto-grants-2013_10
特許番号
US08552186B2

反応ノート

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