Triethylamine → HCID 86669120、化合物

HRID 1041830

反応式

HRID 1041830 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](O)=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1.C(N(CC)CC)C.[F:22][C:23]([F:36])([F:35])[S:24]([O:27]S(C(F)(F)F)(=O)=O)(=[O:26])=[O:25]>CN(C)C1C=CN=CC=1.ClCCl>[F:22][C:23]([F:36])([F:35])[S:24]([OH:27])(=[O:26])=[O:25].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1

参加物

6

反応物 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 831204-Chloro-2-cyclohexylphenol

生成物 1

HCID 86669120HCID 86669120、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

反応条件

温度
-5 °C

実験手順

19 g (90.2 mmol) of 4-chloro-2-cyclohexylphenol, 4.64 ml (33.18 mmol) of triethylamine and 223 mg (1.8 mmol) of 4-(dimethylamino)pyridine are dissolved in 264 ml of dichloromethane, the mixture is cooled to −5° C., and 29.6 ml (180 mmol) of trifluoromethanesulfonic anhydride are added dropwise. The batch is stirred overnight at room temperature and filtered through silica gel with dichloromethane, giving the product 7, which is employed in the next step without further purification.

後処理

  1. filtrationfiltered through silica gel with dichloromethane

出典と根拠

ORDレコード
ord-55f07e4467df4f35a9840a534c5bfa5b
出典データセット
uspto-grants-2013_10
特許番号
US08557142B2

関連ノート

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