Dichloromethane → HCID 178511701、化合物
反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:31][CH2:32][N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)[CH:25]=4)=[N:22][N:23]=3)[CH:20]=2)[CH2:10][CH2:9]1)(C)(C)C.C(Cl)Cl.[C:43]([OH:49])([C:45]([F:48])([F:47])[F:46])=[O:44]>>[F:46][C:45]([F:48])([F:47])[C:43]([OH:49])=[O:44].[N:33]1([CH2:32][CH2:31][O:30][C:26]2[CH:25]=[C:24]([C:21]3[N:19]4[CH:20]=[C:15]([O:14][C@H:11]5[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]5)[CH:16]=[CH:17][C:18]4=[N:23][N:22]=3)[CH:29]=[CH:28][CH:27]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1参加物
4
実験手順
A solution of Example 14 step a (196 mg, 0.178 mmol) in TFA (2 mL) and DCM (10 mL) was stirred at RT for 0.5 H, then concentrated in vacuo to give the title compound (quantitative yield). LCMS (Method 2): Rt 0.38 min, m/z 438 [M-CF3CO2+].
後処理
- concentrationconcentrated in vacuo