Methyl morpholine oxide → 1-(8-Bromoquinolin-2-yl)ethane-1,2-diol
反応式
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=C(C=C)[CH:8]=[CH:7]2.C[N+]1([O-])CC[O:18]CC1.[CH3:22][C:23]([CH3:25])=[O:24].O>ClCCl.O=[Os](=O)(=O)=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:22]([CH:23]([OH:24])[CH2:25][OH:18])[CH:8]=[CH:7]2参加物
6
実験手順
To 8-bromo-2-vinylquinoline (0.886 g, 3.78 mmol) in acetone/H2O (8 mL/2 mL) was added 4-methylmorpholine N-oxide (1.06 g, 4.54 mmol) followed by OsO4 (0.5 mL, 2.5% in t-BuOH). The reaction mixture was stirred for two hours at ambient temperature then diluted with dichloromethane. The organic layer was washed with saturated sodium sulfate and brine and concentrated to give crude product.
後処理
- washThe organic layer was washed with saturated sodium sulfate and brine
- concentrationconcentrated
- customto give crude product
出典と根拠
- ORDレコード
- ord-10c4ca74f28442ce835b3cd9e3e5d290
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08557809B2
反応ノート
読み込み中…