Cyanuric chloride → Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

HRID 10425

反応式

HRID 10425 の反応式
[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:8]2)(=O)[NH2:2].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C)C=O>[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:8]2)#[N:2]

参加物

4

反応物 2

HCID 7954Cyanuric chlorideHCID 90895673HCID 90895673、化合物

生成物 1

HCID 91321587Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

100 mg of tert-butyl ((2R,5S,7aS)-5-carbamoyl-3-oxohexahydropyrrolizin-2-yl)carbamate were dissolved in 2 ml of dimethylformamide, and 65 mg of cyanuric chloride were added. The mixture was stirred for 3 h, and the dimethylformamide was removed in vacuo. The residue was chromatographed on silica gel.

後処理

  1. customthe dimethylformamide was removed in vacuo
  2. customThe residue was chromatographed on silica gel

出典と根拠

ORDレコード
ord-93eff2bf0daa450c897e724582f37625
出典データセット
uspto-grants-2006_08
特許番号
US07094800B2

関連ノート

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