ホーム MCP ワークベンチ Skills

ホームワークベンチ通知マイページ

llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

ホーム
反応

Benzene → 7-(3,5-dimethyl-4-isoxazolyl)-1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

HRID 1043019

印刷プレビュー

反応式

HRID 1043019 の反応式

[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:20][CH2:21][C:22]4[S:26][C:25]([CH3:27])=[N:24][C:23]=4[CH3:28])=[C:12](C(N)=O)[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:29][CH3:30])=[C:5]([CH3:31])[O:4][N:3]=1.C1C=CC=CC=1.[OH2:38].[C:39](#[N:41])C>>[CH3:1][C:2]1[C:6]([C:7]2[C:8]([O:29][CH3:30])=[CH:9][C:10]3[C:11]4[N:20]([CH2:21][C:22]5[S:26][C:25]([CH3:27])=[N:24][C:23]=5[CH3:28])[C:39](=[O:38])[NH:41][C:12]=4[CH:13]=[N:14][C:15]=3[CH:16]=2)=[C:5]([CH3:31])[O:4][N:3]=1

参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 4

HCID 241Benzene

HCID 6342Acetonitrile

HCID 574655937-(3,5-Dimethyl-4-isoxazolyl)-4-{[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide

生成物 1

HCID 529345057-(3,5-dimethyl-4-isoxazolyl)-1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

実験手順

To a solution of 7-(3,5-dimethyl-4-isoxazolyl)-4-{[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide (for a preparation see intermediate 65, 0.3 g) in acetonitrile (50 ml) was added bis(trifluoroacetoxy)iodo]benzene (0.443 g) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was then poured into water and extracted with DCM. The organic phase was dried over Na2SO4 and concentrated to dryness to give an orange oil. The residue was purified by flash chromatography on silica gel eluting with DCM/methanol (98: 2 then 97:3) give a sticky pale yellow solid, which was triturated in hot diisopropylether to give 7-(3,5-dimethyl-4-isoxazolyl)-1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one (0.21 g) as a cream coloured solid.

後処理

extractionextracted with DCM
dry with materialThe organic phase was dried over Na2SO4
concentrationconcentrated to dryness
customto give an orange oil
customThe residue was purified by flash chromatography on silica gel eluting with DCM/methanol (98: 2
custom97:3) give a sticky pale yellow solid, which
customwas triturated in hot diisopropylether

出典と根拠

ORDレコード: ord-9c3e7c1e47a742ac843f4a3fdba6e8ae
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08557984B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート