3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol

HRID 1043059

反応式

HRID 1043059 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH:11][CH3:12].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].CO>C1COCC1.C(Cl)Cl>[CH3:10][N:11]([CH2:5][C:4]1[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=1)[CH3:12]

参加物

7

反応物 4

HCID 1013-HydroxybenzaldehydeHCID 674DimethylamineHCID 887MethanolHCID 5049666Sodium triacetoxyborohydride

生成物 1

HCID 328963-(Dimethylaminomethyl)phenol

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.

後処理

  1. customchromatographed on silica gel with 2-25% ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-a87bbf9c63684d14a3aff343df0d7a24
出典データセット
uspto-grants-2013_10
特許番号
US08557983B2

関連ノート

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