Hydrochloric Acid → 1-((2-chlorothiazol-5-yl)methyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epoxyimidazo[1,2-a]azepine

HRID 1043521ノート

反応式

HRID 1043521 の反応式
[Cl:1][C:2]1[S:3][C:4]([CH2:7][N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[CH:13][N+:14]([O-:16])=[O:15])=[CH:5][N:6]=1.[CH:17](=[O:22])[CH2:18][CH2:19][CH:20]=O.Cl>C(#N)C>[Cl:1][C:2]1[S:3][C:4]([CH2:7][N:8]2[C:9]3=[C:13]([N+:14]([O-:16])=[O:15])[CH:20]4[O:22][CH:17]([N:10]3[CH2:11][CH2:12]2)[CH2:18][CH2:19]4)=[CH:5][N:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 12524ButanedialHCID 1845972-Chloro-5-((2-(nitromethylene)-1-imidazolidinyl)methyl)thiazole

生成物 1

HCID 584962571-((2-chlorothiazol-5-yl)methyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epoxyimidazo[1,2-a]azepine収率 63%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a 50 ml round bottom flask was added 1.30 g (0.005 mol) 1-((2-chlorothiazol-5-yl)methyl)-2-(nitromethylene)imidazolidine, 30 ml dry acetonitrile, 0.860 g (0.01 mol) succinaldehyde and catalytic concentrated HCl. The reaction was stirred at r.t. and monitored by TLC. After completion, the mixture was evaporated to remove solvent and purified by column chromatography to afford final product as faint yellow powder with 63% yield.

後処理

  1. customAfter completion, the mixture was evaporated
  2. customto remove solvent
  3. custompurified by column chromatography

出典と根拠

ORDレコード
ord-3aacaae674ad447083b75dfccc4eb126
出典データセット
uspto-grants-2013_10
特許番号
US08563546B2

反応ノート

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