Ammonium Chloride → 2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide

HRID 1043615ノート

反応式

HRID 1043615 の反応式
[Cl:1][C:2]1[N:3]=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]2[N:11]=[C:10]([C:12](O)=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1.[Cl-].[NH4+].C[N:24](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.O>[Cl:1][C:2]1[N:3]=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]2[N:11]=[C:10]([C:12]([NH2:24])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

7

反応物 4

HCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 584050092-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxylic acid

生成物 1

HCID 584050312-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxylic acid from Example 118 (0.12 g) was reacted with ammonium chloride (7 eq), HATU (1.5 eq) and DIPEA (4 eq) in DMF (5.2 mL) for 30 minutes. The reaction mixture was then diluted with water and the orange solid was collected by filtration to give 90 mg of 2-chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide.

後処理

  1. filtrationthe orange solid was collected by filtration

出典と根拠

ORDレコード
ord-e5c214ab3fff4b8ca17d5e24c8ce133b
出典データセット
uspto-grants-2013_10
特許番号
US08563540B2

反応ノート

読み込み中…