2-[(1-Methyl-4-piperidinyl)oxy]-5-nitropyridine → 6-[(1-methylpiperidin-4-yl)oxy]pyridin-3-amine

HRID 1043775ノート

反応式

HRID 1043775 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][N:10]=2)[CH2:4][CH2:3]1.[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]2[N:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=2)[CH2:6][CH2:7]1

参加物

5

反応物 2

HCID 529048992-[(1-Methyl-4-piperidinyl)oxy]-5-nitropyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 283176056-[(1-methylpiperidin-4-yl)oxy]pyridin-3-amine収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-(1-Methylpiperidin-4-yloxy)-5-nitropyridine (100 mg, 0.42 mmol) was dissolved in 5 mL of methanol and placed under a nitrogen atmosphere. A catalytic amount of 10% palladium on carbon was added and a hydrogen balloon connected to the reaction flask. The flask was flushed five times with hydrogen and stirred at room temperature under hydrogen atmosphere. The solid was filtered and washed with methanol. The filtrate was evaporated under reduced pressure to yield 6-(1-methylpiperidin-4-yloxy)pyridin-3-amine as a brown solid (85 mg, 98%). LC/MS (m/z): 2082 (MH+), Rt 0.34 minutes.

後処理

  1. customThe flask was flushed five times with hydrogen
  2. filtrationThe solid was filtered
  3. washwashed with methanol
  4. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-f20905eac33e4850a12cf399388b048b
出典データセット
uspto-grants-2013_10
特許番号
US08563549B2

反応ノート

読み込み中…