3-Chloropropionyl chloride → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

HRID 1043823

反応式

HRID 1043823 の反応式
C([N:8]1[CH2:17][CH2:16][C:15]2[N:14]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=[CH:11][C:10]=2[CH2:9]1)C1C=CC=CC=1.ClCCC(Cl)=O>ClCCl>[F:21][C:18]([F:19])([F:20])[C:13]1[CH:12]=[CH:11][C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[N:14]=1

参加物

4

反応物 2

HCID 693643-Chloropropionyl chlorideHCID 577709166-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

生成物 1

HCID 534719842-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

To a solution of 5 (500 mg, 1.7 mmol) in dichoromethane (8 mL) was added compound 6, 3-chloro propionyl chloride (0.22 mL, 2.1 mmol) and the reaction mixture was stirred at 40° C. for 18 h. The reaction was then cooled to room temperature and concentrated. The resulting residue was dissolved in methanol (16 mL) and stirred at 40° C. for 3 h. The mixture was then cooled to room temperature and concentrated.

後処理

  1. temperatureThe reaction was then cooled to room temperature
  2. concentrationconcentrated
  3. dissolutionThe resulting residue was dissolved in methanol (16 mL)
  4. stirringstirred at 40° C. for 3 h
  5. temperatureThe mixture was then cooled to room temperature
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-ea0d4bec166348a088b680e664e78c47
出典データセット
uspto-grants-2013_10
特許番号
US08563566B2

関連ノート

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