Methyl Benzoate → HCID 178525802、化合物
反応式
[Zn:1].[C:2]([O:10][CH2:11][I:12])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OC)(=O)C1C=CC=CC=1>C1COCC1>[I-:12].[C:2]([O:10][CH2:11][Zn+:1])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
5
反応条件
- 温度
- 10 °C
実験手順
Title compound was prepared according to the procedure described in: Silhar, P.; Pohl, R.; Votruba, I.; Hocek, M. Org. Lett. 2004, 6, 3225. To a 10° C. solution of zinc (dust) (0.604 g, 9.24 mmol) in THF (1.7 mL) was added a solution of iodomethyl benzoate Part A (1.21 g, 4.62 mmol) in THF (2.1 mL) and the reaction was stirred at 10° C. 1.5 h. Reaction monitored by LCMS by observing the formation of hydrolyzed product (methyl benzoate). Material was used in the next step without purification as a 0.9 M THF solution.
後処理
- custom1.5 h
- customReaction
- customMaterial was used in the next step without purification as a 0.9 M THF solution
出典と根拠
- ORDレコード
- ord-3c921e4ef0334b3da852c1c902543155
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08563583B2
反応ノート
読み込み中…