Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

HRID 1044580ノート

反応式

HRID 1044580 の反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 22707864HCID 22707864、化合物

生成物 1

HCID 227078634-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 4-[2-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.61 mmol) in methylene chloride (5 mL) was added trifluoroacetic acid (2.5 mL). After being stirred at room temperature for 45 min, the solution was concentrated to give an oil. MS calculated for C12H12F3N: (M+H) 228; found 228.1.

後処理

  1. concentrationthe solution was concentrated
  2. customto give an oil

出典と根拠

ORDレコード
ord-6b71f588994b49d683d35f641d06a239
出典データセット
uspto-grants-2013_10
特許番号
US08563582B2

反応ノート

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