2-Methyl-2-(3-nitropropyl)-1,3-dioxolane → 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

HRID 1044733ノート

反応式

HRID 1044733 の反応式
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][N+:10]([O-])=O)[O:6][CH2:5][CH2:4][O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][NH2:10])[O:6][CH2:5][CH2:4][O:3]1

参加物

4

反応物 1

HCID 6383462-Methyl-2-(3-nitropropyl)-1,3-dioxolane

生成物 1

HCID 5600073-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar, a mixture of 2-methyl-2-(3-nitro-propyl)-[1,3]dioxolane (1.80 g, 10.27 mmol) and Pd/C 10% (176 mg) in dry MeOH (35 mL) was stirred at rt under atmospheric H2 for 11 h. The reaction mixture was then filtered and concentrated under reduced pressure to give the title compound as a colorless oil. LC-MS-conditions 02: tR=0.25 min; [M+H]+=146.41.

後処理

  1. customIn a flame dried round-bottomed flask equipped with a magnetic stir bar
  2. filtrationThe reaction mixture was then filtered
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-2f1e704c1227438da0f54ac674e12714
出典データセット
uspto-grants-2013_10
特許番号
US08563714B2

反応ノート

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