HCID 68956549、化合物 → HCID 68654072、化合物
反応式
C([O:8][C:9](=[O:26])[CH2:10][C:11]1[CH:12]=[C:13]([CH:23]=[CH:24][CH:25]=1)[O:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21]C)=[O:19])C1C=CC=CC=1>CO.[Pd]>[CH3:21][O:20][C:18](=[O:19])[CH2:17][CH2:16][CH2:15][O:14][C:13]1[CH:12]=[C:11]([CH2:10][C:9]([OH:26])=[O:8])[CH:25]=[CH:24][CH:23]=1参加物
4
実験手順
The mixture of ethyl 4-(3-(2-(benzyloxy)-2-oxoethyl)phenoxy)butanoate (2.05 g, 5.77 mmol) and Pd/C (0.207 g) in methanol was stirred at room temperature under H2 overnight. The mixture was filtered and the filtrate was concentrated under reduce pressure. The residue was washed with ether, filtrated and dried to obtain 2-(3-(4-methoxy-4-oxobutoxy)phenyl)acetic acid (compound 0202-35) (1 g, 66%): LCMS: 267 [M+1]+.
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
- washThe residue was washed with ether
- filtrationfiltrated
- customdried
出典と根拠
- ORDレコード
- ord-32ff7247a0854a389a7a3231a183426d
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08563741B2
反応ノート
読み込み中…