Dimethylformamide → HCID 67043412、化合物
反応式
[F:1][C:2]1[C:10]2[S:9](=[O:12])(=[O:11])[NH:8][C:7](=O)[C:6]=2[CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O.CN(C=O)C>O1CCOCC1>[Cl:16][C:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([F:1])[C:10]=2[S:9](=[O:12])(=[O:11])[N:8]=1参加物
5
実験手順
3.02 g of 7-fluoro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (EP291851 A2 19881123), 1.64 ml of thionyl chloride and a catalytic amount of DMF in 13 ml of dioxane are heated under reflux for 45 hours. The mixture is concentrated and the residue is crystallized in toluene. 2.50 g of a crude solid is obtained.
後処理
- temperatureunder reflux for 45 hours
- concentrationThe mixture is concentrated
- customthe residue is crystallized in toluene
出典と根拠
- ORDレコード
- ord-869dec3189574e918d0be4123a0eb1d1
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08563744B2
反応ノート
読み込み中…