Trifluoroacetic acid → HCID 67227744、化合物

HRID 1045166ノート

反応式

HRID 1045166 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH:14]([N:16]2[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)[CH3:15])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH:14]([N:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[CH3:15])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67225632HCID 67225632、化合物

生成物 1

HCID 67227744HCID 67227744、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of EXAMPLE 175B (650mg) in dichloromethane (6 mL) was added trifluoroacetic acid (6 mL) at 0° C. The reaction mixture was stirred at 0° C. for 50 minutes and concentrated. The concentrate was dissolved in dichloromethane, washed with aqueous NaHCO3 and the organic layer was dried over Na2SO4, and concentrated.

後処理

  1. concentrationconcentrated
  2. dissolutionThe concentrate was dissolved in dichloromethane
  3. washwashed with aqueous NaHCO3
  4. dry with materialthe organic layer was dried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-1c78b64633594399a6dfda72c8025c7c
出典データセット
uspto-grants-2013_10
特許番号
US08563735B2

反応ノート

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