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Acetic Acid → 2-Nitroacetophenone hydrazone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-Nitro-1-phenylethanone | HCID 94833 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Nitroacetophenone hydrazone | HCID 86657893 | 81.1% |
反応手順
A solution of 2-nitroacetophenone (12.28 g, 0.074 mol) in ethanol (100 mL) was treated with hydrazine hydrate (10.24 g, 0.163 mol) and glacial acetic acid (4.2 mL, 0.074 mol) and the mixture was heated at reflux for 3 hours. The solvent was then evaporated in vacuo. The residue was dissolved in trichloromethane and extracted three times with water to remove the excess of hydrazine hydrate. Evaporation of the organic layer yielded the product (11 g, 0.06 mol, 81%), which was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08569259B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-f717f6b035134c5f95e546611fba502b |
| 出典メモ | uspto-grants-2013_10 |