反应详情

A solution of 2-nitroacetophenone (12.28 g, 0.074 mol) in ethanol (100 mL) was treated with hydrazine hydrate (10.24 g, 0.163 mol) and glacial acetic acid (4.2 mL, 0.074 mol) and the mixture was heated at reflux for 3 hours. The solvent was then evaporated in vacuo. The residue was dissolved in trichloromethane and extracted three times with water to remove the excess of hydrazine hydrate. Evaporation of the organic layer yielded the product (11 g, 0.06 mol, 81%), which was used in the next step without further purification.

1. temperaturethe mixture was heated
2. temperatureat reflux for 3 hours
3. customThe solvent was then evaporated in vacuo
4. dissolutionThe residue was dissolved in trichloromethane
5. extractionextracted three times with water
6. customto remove the excess of hydrazine hydrate
7. customEvaporation of the organic layer