Pyridine → 3'-Methylcinnamanilide

HRID 1045353

反応式

HRID 1045353 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:24])[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>ClCCl>[C:4]1([CH3:8])[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:15](=[O:24])[CH:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 7934m-ToluidineHCID 660233-Phenylprop-2-enoyl chloride

生成物 1

HCID 5830183'-Methylcinnamanilide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

m-Toluidine (5 g, 46.64 mmol) and pyridine (3.77 mL, 46.64 mmol) were dissolved in dry dichloromethane (25 mL). To the reaction mixture, cinnamoyl chloride (7.72 g, 46.64 mmol) was added and stirred for 3 h at 0° C. The reaction mixture was extracted with dichloromethane washing with water and 2N HCl. The solvent was removed and the crude product was used in the next step without further purification.

後処理

  1. extractionThe reaction mixture was extracted with dichloromethane washing with water and 2N HCl
  2. customThe solvent was removed
  3. customthe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-14ca28f2f70a417195f49f94d34eea8b
出典データセット
uspto-grants-2013_10
特許番号
US08569282B2

関連ノート

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