Methyl iodide → HCID 59569552、化合物

HRID 1045368ノート

反応式

HRID 1045368 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[NH:8][C:7](=[O:13])[CH:6]=[CH:5]2.Cl[C:15]1C(C)=C2C(=CC=1)NC(=O)C=C2.C([O-])([O-])=O.[Cs+].[Cs+].IC>CN(C=O)C.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]([CH3:15])[C:7](=[O:13])[CH:6]=[CH:5]2

参加物

7

反応物 4

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 58318186HCID 58318186、化合物HCID 59569575HCID 59569575、化合物

生成物 1

HCID 59569552HCID 59569552、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 6-chloro-7-methylquinolin-2(1H)-one, 6-chloro-5-methylquinolin-2(1H)-one, Cs2CO3, and iodomethane in DMF was heated in a microwave reactor at 100° C. for 30 min. The mixture was diluted with dichloromethane, washed with water and dried over sodium sulfate. After removing the solvent the crude product (600 mg) was used in the next step without purification. MS (ESI) m/z: Calculated for C11H10ClNO: 207.1. found: 208 (M+H)+.

後処理

  1. washwashed with water
  2. dry with materialdried over sodium sulfate
  3. customAfter removing the solvent the crude product (600 mg)
  4. customwas used in the next step without purification

出典と根拠

ORDレコード
ord-51a02f2e985d418ea876fd457c311316
出典データセット
uspto-grants-2013_10
特許番号
US08569282B2

反応ノート

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