Diisopropyl Ether → 3-[N'-(acetyloxy)carbamimidoyl]phenyl acetate

HRID 1045371ノート

反応式

HRID 1045371 の反応式
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[CH:6]=1)[NH2:4].C(N(CC)CC)C.[C:19](OC(=O)C)(=[O:21])[CH3:20].[CH:26]([O:29]C(C)C)(C)[CH3:27]>C(Cl)Cl>[C:19]([O:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([C:3](=[N:2][O:1][C:26](=[O:29])[CH3:27])[NH2:4])[CH:6]=1)(=[O:21])[CH3:20]

参加物

6

反応物 4

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 54381771N,3-dihydroxybenzenecarboximidamide

生成物 1

HCID 866633073-[N'-(acetyloxy)carbamimidoyl]phenyl acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 10.2 g (67 mmol) of the product obtained in Step A above in 150 ml of CH2Cl2 there are added 28 ml (0.201 mol) of triethylamine. 13.9 ml (0.147 mol) of acetic anhydride are added dropwise and the solution is stirred overnight at ambient temperature. After washing 3 times with water and then with brine, the organic phase is dried over MgSO4 and evaporated. The solid obtained is taken up in isopropyl ether and then filtered and dried to yield the title compound.

後処理

  1. washAfter washing 3 times with water
  2. dry with materialwith brine, the organic phase is dried over MgSO4
  3. customevaporated
  4. customThe solid obtained
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-df65c7fb2edb43108c94209531d66d1d
出典データセット
uspto-grants-2013_10
特許番号
US08569285B2

反応ノート

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