Acetic Anhydride → N'-(acetyloxy)-4-iodobenzenecarboximidamide

HRID 1045377ノート

反応式

HRID 1045377 の反応式
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4].C(N(CC)CC)C.[C:19](OC(=O)C)(=[O:21])[CH3:20]>C(Cl)Cl.C(OC(C)C)(C)C>[C:19]([O:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4])(=[O:21])[CH3:20]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 4429393N-Hydroxy-4-iodo-benzamidine

生成物 1

HCID 86663308N'-(acetyloxy)-4-iodobenzenecarboximidamide

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 7914Diisopropyl Ether溶媒

実験手順

To a suspension of the product obtained in Step A above (8.43 g, 32.17 mmol) in 200 ml of CH2Cl2 there are added 6.72 ml (48.2 mmol) of triethylamine. 3.34 ml (35.4 mmol) of acetic anhydride are added dropwise and the solution is stirred overnight at ambient temperature. After washing 3 times with water and then with brine, the organic phase is dried over MgSO4 and evaporated. The solid obtained is taken up in isopropyl ether and then filtered to yield the title product.

後処理

  1. washAfter washing 3 times with water
  2. dry with materialwith brine, the organic phase is dried over MgSO4
  3. customevaporated
  4. customThe solid obtained
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-8dc8ac9c5a664b2bb408d871c4126b8e
出典データセット
uspto-grants-2013_10
特許番号
US08569285B2

反応ノート

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