N,N,1-trimethyl-4-nitropyrazole-3-carboxamide → 4-Amino-N,N,1-trimethyl-1H-pyrazole-3-carboxamide
反応式
[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[C:9]([N+:10]([O-])=O)=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]>CO.[Pd]>[NH2:10][C:9]1[C:5]([C:3]([N:2]([CH3:14])[CH3:1])=[O:4])=[N:6][N:7]([CH3:13])[CH:8]=1参加物
4
実験手順
N,N,1-Trimethyl-4-nitropyrazole-3-carboxamide (1.22 g) was dissolved in MeOH (35 ml) and 10% Pd/C (0.3 g, 50% wet) was added. The mixture was stirred under a hydrogen atmosphere overnight and the catalyst filtered off. The solvent was removed in vacuo to yield 4-amino-N,N,1-trimethylpyrazole-3-carboxamide, 810 mg. NMR Spectrum: (CDCl3) 3.06 (m, 3H), 3.44 (m, 3H), 3.78 (s, 3H), 4.51 (m, 2H), 6.90 (s, 1H); Mass spectrum: MH+ 169
後処理
- filtrationthe catalyst filtered off
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-3877ac76c5854fd19a2bf794ec5b1ec7
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569298B2
反応ノート
読み込み中…