Ethyl 2-cyano-3-ethoxy-2-butenoate → Ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate
反応式
[C:1]([C:3](=[C:9]([O:11][CH2:12][CH3:13])[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[C:1]([C:3](=[C:9]([O:11][CH2:12][CH3:13])[CH:10]=[CH:16][N:17]([CH3:19])[CH3:18])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]参加物
3
反応条件
- 温度
- 70 °C
実験手順
A mixture of ethyl 2-cyano-3-ethoxybut-2-enoate (194 g theory, 1.06 mol) and N,N-dimethylformamide dimethyl acetal (160 g, 1.325 mol) was stirred at 70° C. for 2 hours. The mixture was concentrated under high vacuum to provide crude ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-dienoate. The residue was used directly without further purification.
後処理
- concentrationThe mixture was concentrated under high vacuum
出典と根拠
- ORDレコード
- ord-42b4674ae4bd4d4491db943b6f21a621
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569319B2
反応ノート
読み込み中…