Ethanol → Lamivudine

HRID 1046040

反応式

HRID 1046040 の反応式
[CH2:1]1[S:5][C@H:4]([CH2:6][OH:7])[O:3][C@@H:2]1[N:8]1[C:13](=[O:14])[N:12]=[C:11]([NH2:15])[CH:10]=[CH:9]1.C([O-])(=O)C([O-])=O.C(O)C>C(N(CC)CC)C>[CH2:1]1[S:5][C@H:4]([CH2:6][OH:7])[O:3][C@@H:2]1[N:8]1[C:13](=[O:14])[N:12]=[C:11]([NH2:15])[CH:10]=[CH:9]1

参加物

4

反応物 2

HCID 702EthanolHCID 86677229HCID 86677229、化合物

生成物 1

HCID 60825Lamivudine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

Specifically, Lamivudine oxalate is added to ethanol, and an amount of triethylamine is added thereto at the temperature of 40˜45° C. for 0.5 hr, and stirred for 4 h at the same temperature. The mixture is centrifuged at room temperature, and a product is dried under vacuum at the temperature of 40˜45° C. to obtain Lamivudine crystal.

後処理

  1. customis centrifuged at room temperature
  2. customa product is dried under vacuum at the temperature of 40˜45° C.

出典と根拠

ORDレコード
ord-eb7e2ad85efd4d20b3416678baf39123
出典データセット
uspto-grants-2013_10
特許番号
US08569322B2

関連ノート

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