Ethanol → Lamivudine

HRID 1046041

反応式

HRID 1046041 の反応式
C(O)C.[CH2:4]1[S:8][C@H:7]([CH2:9][OH:10])[O:6][C@@H:5]1[N:11]1[C:16](=[O:17])[N:15]=[C:14]([NH2:18])[CH:13]=[CH:12]1.C([O-])(=O)C([O-])=O>C(N(CC)CC)C>[CH2:4]1[S:8][C@H:7]([CH2:9][OH:10])[O:6][C@@H:5]1[N:11]1[C:16](=[O:17])[N:15]=[C:14]([NH2:18])[CH:13]=[CH:12]1

参加物

4

反応物 2

HCID 702EthanolHCID 86677229HCID 86677229、化合物

生成物 1

HCID 60825Lamivudine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To 1000 ml of ethanol was added 120 g of Lamivudine oxalate (prepared by the method of the present invention). 60 ml of triethylamine was added thereto at the temperature of 40˜45° C. for 0.5 hour, and stirred at the same temperature for 4 hours. The mixture was centrifuged at room temperature and dried under vacuum at the temperature of 40˜45° C. to obtain Lamivudine crystal.

後処理

  1. customprepared by the method of the present invention)
  2. customwas centrifuged at room temperature
  3. customdried under vacuum at the temperature of 40˜45° C.

出典と根拠

ORDレコード
ord-68b61474faa448258e96bdf8c60bc55c
出典データセット
uspto-grants-2013_10
特許番号
US08569322B2

関連ノート

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