Sodium borohydride → [3-(2-Methanesulphinyl-ethoxy)-phenyl]-methanol
反応式
[CH3:1][S:2]([CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH:10]=[O:11])=[O:3].[BH4-].[Na+]>C(O)C>[CH3:1][S:2]([CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:10][OH:11])[CH:12]=[CH:13][CH:14]=1)=[O:3]参加物
4
実験手順
To a solution of 1.1 g (5.18 mmol) 3-(2-methanesulphinyl-ethoxy)-benzaldehyde in 20 ml ethanol (anhydrous) is added NaBH4 (0.215 g, 5.7 mmol). The reaction mixture is stirred at room temperature for 0.5 h. Then it is poured onto water and extracted with ethyl acetate. The combined organic layers are washed with water and brine, dried over MgSO4, filtered and concentrated in vacuo to afford the title compound as a colorless oil that is of sufficient purity for the next step.
後処理
- additionThen it is poured onto water
- extractionextracted with ethyl acetate
- washThe combined organic layers are washed with water and brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5650063affcf4468b9a1d868358aa9ac
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569317B2
反応ノート
読み込み中…