Trifluoroacetic acid → HCID 178419102、化合物

HRID 10466

反応式

HRID 10466 の反応式
[C:1]1([CH:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3C2CCCCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>C(O)C>[C:30]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 21978293Ethyl 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carboxylate

生成物 1

HCID 178419102HCID 178419102、化合物収率 100.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of ethyl 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carboxylate (Preparation 62) (250 g, 0.530 moles) in absolute ethanol (1250 ml) under an atmosphere of nitrogen was added trifluoroacetic acid (73.5 g, 0.645 moles) and the resultant mixture was heated at 50° C. for 20 hours. The mixture was cooled and the solid was collected by filtration. The filter cake was washed with absolute ethanol (350 ml) and was then dried in vacuo at 50° C. to give the title compound (206.5 g) as a cream coloured fine powder, m.p. >200° C.

後処理

  1. temperatureThe mixture was cooled
  2. filtrationthe solid was collected by filtration
  3. washThe filter cake was washed with absolute ethanol (350 ml)
  4. customwas then dried in vacuo at 50° C.

出典と根拠

ORDレコード
ord-81c01a4908cd47028c7b6659b5d734b4
出典データセット
uspto-grants-2006_08
特許番号
US07094769B2

関連ノート

読み込み中…